Friday 3rd June 2016
- 9.00 Registration
- 14.00-14.20 Inaugural Ceremony
- 14.20-15.15 Opening lecture introduced by Ignarro L. J. (US)
Lefer D.J. (US) “Development of novel hydrogen sulfide therapeutics for translation to the clinic”
- 15.15-15.45 Salloum F. N. (US) “Preventing myocardial ischemia-reperfusion injury and failure with hydrogen sulfide”
15.45-16.00 coffee break
Chair: Kimura H., Nagy P.
- 16.00-16.30 Banerjee R. (US) “Sulfide Biogenesis and Oxidation"
- 16.30-17.00 Papapetropoulos A. (GR) “Sources, targets and pathways: an update of hydrogen sulfide signaling”
- 17.00-17.30 Van Goor H. (NL) “Free thiols and gaseous signaling molecules in health and disease”
Saturday 4th June 2016
Chair: Banerjee R., Pfeilschifter J.
- 9.00-9.30 Kimura H. (JP) “Production and functions of hydrogen sulfide and hydrogen polysulfide”
- 9.30-10.00 Fukuto J. (US) “The Chemical Biology of Hydropersulfides”
- 10.00-10.30 Feelisch M. (UK) “Well Beyond a Simple ‘Cross-Talk’ Story: On the Unique Position of Reactive Sulfur Species in the Redox Metabolome”
- 10.30-11.00 Nagy P. (HU) “Insights into the molecular pathways of persulfide-mediated redox signaling”
11.00-11.15 coffee break
Chair: Fukuto J., Feelisch M.
- 11.15-11.45 Wallace J. L. (CA) "H2S-Based Anti-inflammatory drugs: Lost and Found in Translation"
- 11.45-12.15 Whiteman M. (UK) “Mitochondrial H2S: a viable therapeutic opportunity?”
- 12.15-12.45 Pluth M. (US) “Synthetic H2S donors with defined release mechanisms and tunable release rates”
- 14.00-16.00 POSTER SESSION
Chair: Lefer D. J., Van Goor H.
- 16.00-16.30 Wang R. (CA) “Hydrogen sulfide and asthma”
- 16.30-16.45 Casola A. (US) “Hydrogen sulfide: antiviral and anti-inflammatory in the airways. Role in respiratory syncytial virus infection”
- 16.45-17.00 Palinkas Z. (HU) “Reduction of highly oxidizing heme redox intermediates by H2S and its possible contributions to the antioxidant actions of H2S”
17.00-17.15 coffee break
Chair: Szabo C., Bouillaud F.
- 17.15-17.30 Saini V. (US) “Hydrogen sulfide regulates mycobacterium tubercolosis bioenergetics and progression of tubercolosis disease”
- 17.30-17.45 Greco V. (IT) “Hydrogen sulfide as a new player of amytrophic lateral sclerosis”
- 17.45-18.00 Paul B. D. (US) “Dysregulated ATF4 regulation and imbalanced redox homeostasis caused by cysteine stress mediates neurodegeneration in Huntigton’s disease”
Sunday 5th June 2016
Chair: Wallace J. L., Wang R.
- 9.00-9.30 Kevil C. (US) “Endogenous sulfide regulation of arterial vascular remodeling”
- 9.30-10.00 Mitchell J. (US) “Nutrient restriction triggers angiogenesis via regulation of endogenous H2S production”
- 10.00-10.15 Chatzianastasiou A. (GR) ”Protection against ischemia/reperfusion injury by H2S donors: the role of mitochondria”
- 10.15-10.30 Miao L. (CN) “Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages”
- 10.30-10.45 Karwi Q. (UK) “Molecular mechanism of H2S induced cardioprotection”
10.45-11.00 Coffee break
Chair: Whiteman M., Kevil C.
- 11.00-11.30 Szabo C. (US) “Hydrogen sulfide and cancer: pathomechanisms and therapeutic opportunities”
- 11.30-12.00 Ianaro A. (IT) “Involvement of hydrogen sulfide pathway in human melanoma development and progression”
- 12.00-12.30 Fiorucci S. (IT) “Targeting the bile acid activated receptors gaseous-transmitter axes in the splanchnic and systemic circulation in the treatment of liver and metabolic disorders”
Session co-organized by the “European Network on Gasotransmitters” (BM1005)
Chair: Papapetropoulos A., Bian J.
- 14.00-14.15 Martelli A. (IT) “Vascular Effects of p-Carboxyphenyl-Isothiocyanate, a novel H2S-donor”
- 14.15-14.30 Bouillaud F. (FR) “The activity of the sulfide oxidation pathway fine-tunes cellular affinity for oxygen”
- 14.30-14.45 Bian J. (SG) “Hydrogen sulfide inhibits RAGE toxicity through reducing the dimer formation
- 14.45-15.00 Szczesny B. (US) “Inhibition of H2S biosynthesis sensitizes lung adenocarcinoma cells to genotoxic agents”
- 15.00-15.15 Cao X. (SG) “Hydrogen Sulfide Attenuates Cisplatin-induced Nephrotoxicity without Compromising its Anti-cancer Benefit”
- 15.15-15.30 Giuffrè A. (IT) “Sulfide-resistant Bacterial Respiration: a New Role for Cytochrome bd Oxidase”
- 15.30-15.45 Lobb I. (CA) “Mitochondrial-targeted hydrogen sulfide release by AP39 improves renal graft function and survival following prolonged cold storage and transplantation and protects renal epithelial cells from in vitro cold hypoxia/hypercapnia and re-oxygenation injury”
- 15.45-16.00 Corvino A. (IT) “Design and synthesis of non covalent CSE inhibitors evaluated by hybrid methods”
- 16.00-16.15 Longen S. (DE) “A Proteomic Approach for the Identification of Persulfides in Mammalian Cells”
- 16.15 Concluding Remarks